Trixaicin Topical

Generic Name: capsaicin (Topical route)

kap-SAY-sin

Commonly used brand name(s)

In the U.S.

• Arthricare For Women


• Capsagel


• Capsagesic-HP Arthritis Relief


• Capsin


• Double Cap


• Icy Hot Arthritis Therapy


• Pain Enz


• Rid-A-Pain


• Sportsmed


• Therapatch Warm


• Trixaicin


• Zostrix

Available Dosage Forms:

• Lotion


• Cream


• Gel/Jelly


• Patch, Extended Release


• Film


• Pad


• Ointment


• Liquid


• Stick

Therapeutic Class: Analgesic

Uses For Trixaicin

Capsaicin is used to help relieve a certain type of pain known as neuralgia (shingles). Capsaicin is also used to help relieve minor pain associated with rheumatoid arthritis or muscle sprains and strains. This medicine will not cure any of these conditions.

Neuralgia is a pain that comes from the nerves near the surface of your skin. This pain may occur after an infection with herpes zoster (shingles or postherpetic neuralgia). Capsaicin will help relieve the pain of postherpetic neuralgia, but it will not cure the condition.

This medicine is available both over-the-counter (OTC) and with your doctor's prescription.

Before Using Trixaicin

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of capsaicin in children. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of capsaicin in the elderly.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Heart or blood vessel problems, history of or


• Hypertension (high blood pressure), unstable—Use the Qutenza™ patch with caution. May cause side effects to become worse.

• Infection at application area or


• Large sores, broken, or irritated skin at application area—Use with caution. May cause side effects to become worse.

Proper Use of capsaicin

This section provides information on the proper use of a number of products that contain capsaicin. It may not be specific to Trixaicin. Please read with care.

A nurse or other trained healthcare professional will apply the topical Qutenza™ patch to the affected area.

If you are using the topical cream, gel, lotion, or ointment for neuralgia, muscle pain, or arthritis, follow the instructions on the medicine label.

Be careful not to get any of this medicine in your eyes, because it can cause severe eye irritation. If the medicine does get in your eyes, wash the eyes with water and check with your doctor right away.

If capsaicin gets on your face, scalp, or in your mouth, it may cause a burning sensation. Wash these areas with warm (not hot) soapy water.

If you are using the cream, gel, lotion, or ointment:

• Do not put the medicine on wounds or irritated skin.


• Apply a small amount of medicine and use your fingers to rub it in well so very little or no medicine is left on the skin.


• Wash your hands with soap and water after applying the medicine to avoid getting it in your eyes or on other sensitive areas of the body.


• If you are using capsaicin for arthritis in your hands, do not wash your hands for at least 30 minutes after applying it.


• If a bandage is being used on the treated area, do not wrap it tightly.


• Use the medicine regularly every day as directed. It may take a full 2 weeks before your pain goes away.


• If your condition gets worse, or does not improve after one month, stop using the medicine and check with your doctor.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For topical dosage form (cream, gel, lotion, or ointment):
  
  • For arthritis, muscle pain, or neuralgia:
    
    • Adults and teenagers—Apply regularly 3 or 4 times a day and rub in well.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Trixaicin

If you use the Qutenza™ patch:

• Your doctor will check you closely for any problems or unwanted effects that may be caused by this medicine.


• Your blood pressure will be measured while the patch is on your skin and after it has been removed. If you notice any change to your recommended blood pressure at home, call your doctor right away. If you have questions about this, talk to your doctor.


• You may have some skin redness, burning, or a stinging sensation at the application site. Heat, humidity, bathing in warm water, or sweating may increase the burning sensation. If this irritation is severe or does not go away, call your doctor.


• Your skin may be more sensitive to heat and sunlight. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds.


• Check with your doctor right away if you have coughing, shortness of breath, or any breathing problems after the patch is removed.


• Your doctor might give you oral pain medicines (e.g., opioids, narcotics) while the patch is in place and after it is removed. These medicines may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.

If you use the cream, gel, lotion, or ointment:

• You may have some skin redness, burning, or a stinging sensation at the application site. Although this usually disappears after the first several days, it may last 2 to 4 weeks. Heat, humidity, bathing in warm water, or sweating may increase the burning sensation. If this irritation is severe or does not go away, call your doctor.


• The burning sensation will not improve or go away if you reduce the number of doses you use each day. Using fewer doses may also reduce the amount of pain relief you get.


• Your skin may be more sensitive to heat and sunlight. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds.


• Check with your doctor right away if you have coughing, shortness of breath, or any breathing problems after the medicine has dried on the skin.

Trixaicin Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common - all forms

• Burning, itching, dryness, pain, redness, swelling, or soreness at the application site

Less common - all forms

• Cough


• cough-producing mucus


• difficulty with breathing


• shortness of breath or troubled breathing


• sore throat


• stuffy or runny nose


• tightness in the chest or wheezing

Less common - patch only

• Blurred vision


• dizziness


• headache


• nervousness


• pounding in the ears


• slow or fast heartbeat

Incidence not known - patch only

• Bloating or swelling of the face, arms, hands, lower legs, or feet


• increased sensitivity to pain


• increased sensitivity to touch


• rapid weight gain


• tingling in the hands and feet


• unsteadiness or awkwardness


• unusual weight gain or loss


• weakness in the arms, hands, legs, or feet

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common - patch only

• Fever


• muscle aches


• nausea


• pain or tenderness around the eyes and cheekbones


• unusual tiredness or weakness


• vomiting

Incidence not known - patch only

• Abnormal skin color


• change in taste


• loss of taste

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Trixaicin Topical side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Trixaicin Topical resources

• Trixaicin Topical Side Effects (in more detail)
• Trixaicin Topical Use in Pregnancy & Breastfeeding
• Trixaicin Topical Drug Interactions
• Trixaicin Topical Support Group
• 0 Reviews for Trixaicin Topical - Add your own review/rating

Compare Trixaicin Topical with other medications

• Burning Mouth Syndrome
• Diabetic Nerve Damage
• Osteoarthritis
• Pain
• Persisting Pain, Shingles

Lodine XL

Generic Name: etodolac (Oral route)

e-TOE-doe-lak

Oral route(Tablet;Capsule;Tablet, Extended Release)

NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may be increased in patients with cardiovascular disease or risk factors for cardiovascular disease. Etodolac is contraindicated for the treatment of perioperative pain in the setting of CABG surgery. NSAIDs can also cause an increased risk of serious gastrointestinal adverse events especially in the elderly, including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal .

Commonly used brand name(s)

In the U.S.

• Lodine


• Lodine XL

Available Dosage Forms:

• Tablet


• Capsule


• Tablet, Extended Release

Therapeutic Class: Analgesic

Pharmacologic Class: NSAID

Chemical Class: Acetic Acid (class)

Uses For Lodine XL

Etodolac is a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain, and helps to relieve symptoms of arthritis (osteoarthritis and rheumatoid arthritis), such as inflammation, swelling, stiffness, and joint pain. However, this medicine does not cure arthritis and will help you only as long as you continue to take it .

This medicine is available only with your doctor's prescription .

Before Using Lodine XL

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of etodolac capsules and tablets in children below 18 years of age. No studies have also been done on the relationship of etodolac extended-release tablets in children below 6 years of age. Safety and efficacy have not been established in these age groups .

Geriatric

Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of etodolac in the elderly. However, elderly patients may be more sensitive to the effects of etodolac than younger adults, and are more likely to have age-related kidney problems, which may require adjustment of dosage in patients receiving etodolac .

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Ketorolac


• Pentoxifylline

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Abciximab


• Ardeparin


• Argatroban


• Beta Glucan


• Bivalirudin


• Certoparin


• Cilostazol


• Citalopram


• Clopidogrel


• Clovoxamine


• Dabigatran Etexilate


• Dalteparin


• Danaparoid


• Desirudin


• Dipyridamole


• Enoxaparin


• Escitalopram


• Femoxetine


• Flesinoxan


• Fluoxetine


• Fluvoxamine


• Fondaparinux


• Ginkgo


• Heparin


• Lepirudin


• Methotrexate


• Nadroparin


• Nefazodone


• Parnaparin


• Paroxetine


• Pemetrexed


• Protein C


• Reviparin


• Rivaroxaban


• Sertraline


• Sibutramine


• Tacrolimus


• Ticlopidine


• Tinzaparin


• Tirofiban


• Vilazodone


• Zimeldine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acebutolol


• Acenocoumarol


• Acetohexamide


• Alacepril


• Alprenolol


• Amiloride


• Arotinolol


• Atenolol


• Azilsartan Medoxomil


• Azosemide


• Befunolol


• Bemetizide


• Benazepril


• Bendroflumethiazide


• Benzthiazide


• Betaxolol


• Bevantolol


• Bisoprolol


• Bopindolol


• Bucindolol


• Bumetanide


• Bupranolol


• Buthiazide


• Candesartan Cilexetil


• Canrenoate


• Captopril


• Carteolol


• Carvedilol


• Celiprolol


• Chlorothiazide


• Chlorpropamide


• Chlorthalidone


• Cilazapril


• Clopamide


• Cyclopenthiazide


• Cyclosporine


• Delapril


• Desvenlafaxine


• Dicumarol


• Dilevalol


• Duloxetine


• Enalaprilat


• Enalapril Maleate


• Eprosartan


• Esmolol


• Ethacrynic Acid


• Fosinopril


• Furosemide


• Gliclazide


• Glimepiride


• Glipizide


• Gliquidone


• Glyburide


• Hydrochlorothiazide


• Hydroflumethiazide


• Imidapril


• Indapamide


• Irbesartan


• Labetalol


• Landiolol


• Levobetaxolol


• Levobunolol


• Lisinopril


• Losartan


• Mepindolol


• Methyclothiazide


• Metipranolol


• Metolazone


• Metoprolol


• Milnacipran


• Moexipril


• Nadolol


• Nebivolol


• Nipradilol


• Olmesartan Medoxomil


• Oxprenolol


• Penbutolol


• Pentopril


• Perindopril


• Phenprocoumon


• Pindolol


• Piretanide


• Polythiazide


• Propranolol


• Quinapril


• Ramipril


• Sotalol


• Spirapril


• Spironolactone


• Talinolol


• Tasosartan


• Telmisartan


• Temocapril


• Tertatolol


• Timolol


• Tolazamide


• Tolbutamide


• Torsemide


• Trandolapril


• Triamterene


• Trichlormethiazide


• Valsartan


• Venlafaxine


• Xipamide


• Zofenopril

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Anemia or


• Asthma or


• Bleeding problems or


• Blood clots or


• Edema (fluid retention or body swelling) or


• Heart attack, history of or


• Heart disease (e.g., congestive heart failure) or


• High blood pressure or


• Kidney disease or


• Liver disease (e.g., hepatitis) or


• Stomach or intestinal ulcers or bleeding or


• Stroke, history of—Use with caution. This medicine may make these conditions worse .

• Aspirin sensitivity, history of—This medicine should NOT be used in patients with this condition .

• Heart surgery (e.g., coronary artery bypass graft [CABG] surgery)—This medicine should NOT be used to relieve pain right before or after the surgery .

Proper Use of etodolac

This section provides information on the proper use of a number of products that contain etodolac. It may not be specific to Lodine XL. Please read with care.

For safe and effective use of this medicine, do not take more of it, do not take it more often, and do not take it for a longer time than ordered by your doctor. Taking too much of this medicine may increase the chance of unwanted effects, especially in elderly patients .

When used for severe or continuing arthritis, this medicine must be taken regularly as ordered by your doctor in order for it to help you. This medicine usually begins to work within one week, but in severe cases up to two weeks or even longer may pass before you begin to feel better. Also, several weeks may pass before you feel the full effects of this medicine.

Swallow the extended-release tablet whole. Do not crush, break, or chew it.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For acute pain:
  
  • For oral dosage form (capsules or tablets):
    
    • Adults—200 to 400 milligrams (mg) every 6 to 8 hours. However, the dose usually is not more than 1000 mg per day.
    
    
    • Children—Use and dose must be determined by your doctor .
    
    
  
  

• For osteoarthritis and rheumatoid arthritis:
  
  • For oral dosage form (capsules or tablets):
    
    • Adults—300 mg two or three times a day, or 400 or 500 mg two times a day. If you will be taking this medicine for a long time, your doctor may lower your dose to 600 mg once a day. The dose usually is not more than 1000 mg per day.
    
    
    • Children—Use and dose must be determined by your doctor .
    
    
  
  
  • For oral dosage form (extended-release tablets):
    
    • Adults—400 mg to 1000 mg once a day.
    
    
    • Children 6 to 16 years of age—Dose is based on body weight and must be determined by your doctor.
    
    
    • Children below 6 years of age—Use and dose must be determined by your doctor .
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using Lodine XL

It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it. Blood and urine tests may be needed to check for unwanted effects .

This medicine may raise your risk of having a heart attack or stroke. This is more likely in people who already have heart disease. People who use this medicine for a long time might also have a higher risk .

This medicine may cause bleeding in your stomach or intestines. These problems can happen without warning signs. This is more likely if you have had a stomach ulcer in the past, if you smoke or drink alcohol regularly, if you are over 60 years old, if you are in poor health, or if you are using certain other medicines (a steroid or a blood thinner) .

Serious skin reactions can occur during treatment with this medicine. Check with your doctor right away if you have any of the following symptoms while taking this medicine: blistering, peeling, loosening of skin, chills, cough, diarrhea, fever, itching, joint or muscle pain, red skin lesions, sore throat, sores ulcers, white spots in mouth or on lips, or unusual tiredness or weakness .

Possible warning signs of some serious side effects that can occur during treatment with this medicine may include swelling of the face, fingers, feet, and/or lower legs; severe stomach pain, black, tarry stools, and/or vomiting of blood or material that looks like coffee grounds; unusual weight gain; yellow skin or eyes; decreased urination; unusual bleeding or bruising; and/or skin rash. Also, signs of serious heart problems could occur such as chest pain, tightness in chest, fast or irregular heartbeat, unusual flushing or warmth of skin, weakness, or slurring of speech. Stop taking this medicine and check with your doctor immediately if you notice any of these warning signs .

This medicine may also cause a serious type of allergic reaction called anaphylaxis. Although this is rare, it may occur more often in patients who are allergic to aspirin or to any of the nonsteroidal anti-inflammatory drugs. Anaphylaxis requires immediate medical attention. The most serious signs of this reaction are very fast or irregular breathing, gasping for breath, wheezing, or fainting. Other signs may include changes in color of the skin of the face; very fast but irregular heartbeat or pulse; hive-like swellings on the skin; and puffiness or swellings of the eyelids or around the eyes. If these effects occur, get emergency help at once .

Using this medicine while you are pregnant can harm your unborn baby. If you think you have become pregnant while using the medicine, tell your doctor right away .

Before having any kind of surgery or medical tests, tell your doctor that you are taking this medicine. It may be necessary for you to stop treatment for a while, or to change to a different nonsteroidal anti-inflammatory drug before your procedure .

Lodine XL Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Abdominal or stomach bloating, burning, cramping, or pain


• belching


• bloody or black, tarry stools


• blurred vision


• body aches or pain


• cloudy urine


• congestion


• constipation


• cough or hoarseness


• decrease in urine output or decrease in urine-concentrating ability


• diarrhea


• dizziness


• dryness or soreness of throat


• feeling of indigestion


• fever or chills


• headache


• increased bleeding time


• itching skin


• loss of appetite


• lower back or side pain


• nausea and vomiting


• nervousness


• pain in the chest below the breastbone


• painful or difficult urination


• pale skin


• pounding in the ears


• rash


• runny nose


• severe stomach pain


• slow or fast heartbeat


• swelling


• tender, swollen glands in neck


• trouble in swallowing


• troubled breathing with exertion


• unusual bleeding or bruising


• unusual tiredness or weakness


• voice changes


• vomiting of blood or material that looks like coffee grounds


• weight loss

Symptoms of overdose

• Agitation


• change in consciousness


• confusion


• depression


• difficult or troubled breathing


• hives


• hostility


• irregular, fast or slow, or shallow breathing


• irritability


• loss of consciousness


• muscle twitching


• pain or discomfort in chest, upper stomach, or throat


• pale or blue lips, fingernails, or skin


• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue


• rapid weight gain


• seizures


• shortness of breath


• sleepiness


• stupor


• swelling of face, ankles, or hands


• tightness in chest


• unusual drowsiness, dullness, or feeling of sluggishness


• wheezing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Bloated, full feeling


• continuing ringing or buzzing or other unexplained noise in ears


• excess air or gas in stomach or intestines


• hearing loss


• lack or loss of strength


• passing gas


• sneezing


• stuffy nose

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Lodine XL side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Lodine XL resources

• Lodine XL Side Effects (in more detail)
• Lodine XL Use in Pregnancy & Breastfeeding
• Drug Images
• Lodine XL Drug Interactions
• Lodine XL Support Group
• 0 Reviews for Lodine XL - Add your own review/rating

• Etodolac Prescribing Information (FDA)


• Etodolac Professional Patient Advice (Wolters Kluwer)


• Etodolac Monograph (AHFS DI)


• Etodolac MedFacts Consumer Leaflet (Wolters Kluwer)


• Lodine Prescribing Information (FDA)


• Lodine Consumer Overview

Compare Lodine XL with other medications

• Juvenile Rheumatoid Arthritis
• Osteoarthritis
• Pain
• Rheumatoid Arthritis

Tenex

Generic Name: guanfacine (GWAHN fa seen)

Brand Names: Intuniv, Tenex

What is Tenex (guanfacine)?

Guanfacine reduces nerve impulses in your heart and blood vessels. Guanfacine works by relaxing blood vessels, which lowers blood pressure and improves blood flow.

Guanfacine is used to treat high blood pressure (hypertension). It is sometimes given together with other blood pressure medications.

Guanfacine is also used to treat attention deficit hyperactivity disorder (ADHD) in children who are at least 6 years old.

Guanfacine may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Tenex (guanfacine)?

You should not use this medication if you are allergic to guanfacine.

Before you take guanfacine, tell your doctor if you have heart disease, heart block, coronary artery disease or a history of stroke, low blood pressure, kidney or liver disease, or if you have recently had a heart attack.

Guanfacine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Avoid drinking alcohol.

To be sure this medication is helping your condition and not causing harmful effects, your doctor will need to check your progress on a regular basis. Your blood pressure and heart rate may also need to be checked. Do not miss any` follow-up visits to your doctor.

If you are being treated for high blood pressure, keep using this medication even if you feel fine. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

Tell your doctor if you regularly use other medicines that make you sleepy. They can add to sleepiness caused by guanfacine.

What should I discuss with my healthcare provider before taking Tenex (guanfacine)?

You should not use this medication if you are allergic to guanfacine.

To make sure you can safely take guanfacine, tell your doctor if you have any of these other conditions:

• 
  

  heart disease or heart block;

  
  


• 
  

  coronary artery disease or a history of stroke;

  
  


• 
  

  low blood pressure;

  
  


• kidney disease;


• liver disease; or


• 
  

  if you have recently had a heart attack.

  
  

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether guanfacine passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take Tenex (guanfacine)?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results.

If you take Intuniv to treat ADHD, take your dose in the morning.

If you take Tenex to treat hypertension, you may need to take your dose at bedtime if guanfacine causes severe drowsiness. Follow your doctor's instructions.

Do not crush, chew, or break an Intuniv extended-release tablet. Swallow the pill whole. Breaking the pill may cause too much of the drug to be released at one time.

If there are any changes in the brand, strength, or type of guanfacine you use, your dosage needs may change. Always check your refills to make sure you have received the correct brand and type of medicine prescribed by your doctor. Ask the pharmacist if you have any questions about the medicine you receive at the pharmacy.

To be sure this medication is helping your condition and not causing harmful effects, your doctor will need to check your progress on a regular basis. Your blood pressure and heart rate may also need to be checked. Do not miss any follow-up visits to your doctor.

Do not stop taking this medication without first talking to your doctor. If you stop taking guanfacine suddenly, your condition may become worse and you could have unpleasant symptoms.

If you are being treated for high blood pressure, keep using this medication even if you feel fine. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Call your doctor for instructions if you miss more than 2 doses in a row.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include drowsiness, dizziness, slow heart rate, or feeling like you might pass out.

What should I avoid while taking Tenex (guanfacine)?

Avoid taking guanfacine with a high-fat meal.

Guanfacine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Avoid becoming overheated or dehydrated during exercise and in hot weather while you are taking guanfacine.

Drinking alcohol can increase certain side effects of guanfacine.

Tenex (guanfacine) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

• 
  

  fast or slow heart rate;

  
  


• 
  

  pounding heartbeats, chest tightness;

  
  


• 
  

  numbness or tingling; or

  
  


• 
  

  feeling like you might pass out.

  
  

Less serious side effects may include:

• 
  

  drowsiness, dizziness, tired feeling;

  
  


• 
  

  dry mouth;

  
  


• 
  

  constipation;

  
  


• 
  

  stomach pain;

  
  


• 
  

  weight gain;

  
  


• 
  

  headache; or

  
  


• 
  

  feeling irritable.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Tenex (guanfacine)?

Before you take guanfacine, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, anxiety, or psychiatric disorders). They can add to sleepiness caused by guanfacine.

Tell your doctor about all other medications you use, especially any other blood pressure medications, or:

• 
  

  bosentan (Tracleer);

  
  


• 
  

  conivaptan (Vaprisol);

  
  


• 
  

  dexamethasone (Decadron, Hexadrol);

  
  


• 
  

  diclofenac (Arthrotec, Cataflam, Voltaren, Flector Patch, Solareze);

  
  


• 
  

  St. John's wort;

  
  


• 
  

  imatinib (Gleevec);

  
  


• 
  

  isoniazid (for treating tuberculosis);

  
  


• 
  

  valproic acid (Depakene, Stavzor);

  
  


• 
  

  an antibiotic such as clarithromycin (Biaxin), dalfopristin/quinupristin (Synercid), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin), rifampin (Rifadin, Rifater, Rifamate), or telithromycin (Ketek);

  
  


• 
  

  antifungal medication such as clotrimazole (Mycelex Troche), itraconazole (Sporanox), ketoconazole (Nizoral), or voriconazole (Vfend);

  
  


• 
  

  an antidepressant such as nefazodone;

  
  


• 
  

  a barbiturate such as butabarbital (Butisol), secobarbital (Seconal), pentobarbital (Nembutal), or phenobarbital (Solfoton);

  
  


• 
  

  a calcium channel blocker such as diltiazem (Cartia, Cardizem), felodipine (Plendil), nifedipine (Nifedical, Procardia), verapamil (Calan, Covera, Isoptin, Verelan), and others;

  
  


• 
  

  HIV or AIDS medicine such as atazanavir (Reyataz), delavirdine (Rescriptor), efavirenz (Sustiva), etravirine (Intelence), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), saquinavir (Invirase), or ritonavir (Norvir); or

  
  


• 
  

  seizure medication such as carbamazepine (Carbatrol, Tegretol), felbamate (Felbatol), oxcarbazepine (Trileptal), phenytoin (Dilantin), or primidone (Mysoline).

  
  

This list is not complete and other drugs may interact with guanfacine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Tenex resources

• Tenex Side Effects (in more detail)
• Tenex Use in Pregnancy & Breastfeeding
• Drug Images
• Tenex Drug Interactions
• Tenex Support Group
• 3 Reviews for Tenex - Add your own review/rating

• Tenex Prescribing Information (FDA)


• Tenex Advanced Consumer (Micromedex) - Includes Dosage Information


• Tenex Monograph (AHFS DI)


• Tenex MedFacts Consumer Leaflet (Wolters Kluwer)


• Guanfacine Prescribing Information (FDA)


• Guanfacine Professional Patient Advice (Wolters Kluwer)


• Intuniv Extended-Release Tablets MedFacts Consumer Leaflet (Wolters Kluwer)


• Intuniv Prescribing Information (FDA)


• Intuniv Consumer Overview

Compare Tenex with other medications

• High Blood Pressure

Where can I get more information?

• Your pharmacist can provide more information about guanfacine.

See also: Tenex side effects (in more detail)

Sulfatol Gel

sulfacetamide sodium and sulfur

Dosage Form: gel
Sulfatol™ Gel (Sodium Sulfacetamide 10%, and Sulfur 5%)

Rx Only

Sulfatol Gel Description

Sodium sulfacetamide is a sulfonamide with antibacterial activity. Sulfur acts as a keratolytic agent. Chemically, sodium sulfacetamide is N-[(4-aminophenyl) sulfonyl]-acetamide, monosodium salt, monohydrate. The structural formula is:

Each mL of Sulfatol™ Gel (Sodium Sulfacetamide 10%, and Sulfur 5% in a Urea vehicle) contains 100 mg of Sodium Sulfacetamide and 50 mg of Sulfur in an emulsion base containing Urea 10%, Benzyl Alcohol, Cetyl Alcohol, Cocoglycerides, Dimethicone, Disodium EDTA, Fragrance, Glyceryl and PEG-100 Stearate, Isopropyl Myristate, Light Mineral Oil, Polysorbate 60, Propylene Glycol, Sodium Thiosulfate, Sorbitan Monostearate, Stearyl Alcohol, Purified Water, Xanthan Gum, and Zinc Ricinoleate.

Clinical Pharmacology

The most widely accepted mechanism of action of sulfonamides is the Woods-Fildes theory, which is based on the fact that sulfonamides act as competitive antagonists to para-aminobenzoic acid (PABA), an essential component for bacterial growth. While absorption through intact skin has not been determined, sodium sulfacetamide is readily absorbed from the gastrointestinal tract when taken orally and excreted in the urine, largely unchanged. The biological half-life has variously been reported as 7 to 12.8 hours. The exact mode of action of sulfur in the treatment of acne is unknown, but it has been reported that it inhibits the growth of Propionibacterium acnes and the formation of free fatty acids.

INDICATIONS

Sulfatol™ Gel is indicated in the topical control of acne vulgaris, acne rosacea and seborrheic dermatitis.

Contraindications

Sulfatol™ Gel is contraindicated for use by patients having known hypersensitivity to sulfonamides, sulfur or any other component of this preparation. Sulfatol™ Gel is not to be used by patients with kidney disease.

Warnings

Although rare, sensitivity to sodium sulfacetamide may occur. Therefore, caution and careful supervision should be observed when prescribing this drug for patients who may be prone to hypersensitivity to topical sulfonamides. Systemic toxic reactions such as agranulocytosis, acute hemolytic anemia, purpura hemorrhagica, drug fever, jaundice, and contact dermatitis indicate hypersensitivity to sulfonamides. Particular caution should be employed if areas of denuded or abraded skin are involved.

FOR EXTERNAL USE ONLY. Keep away from eyes. Keep out of reach of children. Keep tube tightly closed.

Precautions

General

If irritation develops, use of the product should be discontinued and appropriate therapy instituted. Patients should be carefully observed for possible local irritation or sensitization during long-term therapy. The object of this therapy is to achieve desquamation without irritation, but sodium sulfacetamide and sulfur can cause reddening and scaling of the epidermis. These side effects are not unusual in the treatment of acne vulgaris but patients should be cautioned about the possibility.

Information for Patients

Avoid contact with eyes, eyelids, lips and mucous membranes. If accidental contact occurs rinse with water. If excessive irritation develops, discontinue use and consult your physician.

Carcinogenesis, Mutagenesis, and Impairment of Fertility

Long-term studies in animals have not been performed to evaluate carcinogenic potential.

Pregnancy

Category C

Animal reproduction studies have not been conducted with Sulfatol™ Gel. It also is not known whether Sulfatol™ Gel can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Sulfatol™ Gel should be given to a pregnant woman only if clearly needed.

Nursing Mothers

It is not known whether sodium sulfacetamide is excreted in human milk following topical use of Sulfatol™ Gel. However, small amounts of orally administered sulfonamides have been reported to be eliminated in human milk. In view of this and because many drugs are excreted in human milk, caution should be exercised when Sulfatol™ Gel is administered to a nursing woman.

Pediatric Use

Safety and effectiveness in children under the age of 12 have not been established.

Adverse Reactions

Although rare, sodium sulfacetamide may cause local irritation.

Sulfatol Gel Dosage and Administration

Sulfatol Gel: Cleanse affected areas. Apply a thin film of Sulfatol™ Gel to affected areas 1 to 3 times daily, or as directed by a physician.

How is Sulfatol Gel Supplied

Sulfatol™ Gel is available in a 1.5 fl. oz. (45mL) tube. NDC 51991-172-45

Storage

Store at 25° C (77° F); excursions permitted to 15°-30° C (59°-86° F). See USP Controlled Room Temperature.

Protect from freezing. Keep tube tightly closed.

Distributed by: Breckenridge Pharmaceutical, Inc., Boca Raton, FL 33487

Manufactured by: Groupe Parima Inc., Montréal, QC Canada H4S 1X6

06/07

PRINCIPAL DISPLAY PANEL - 45 mL Carton

Breckenridge

Pharmaceutical, Inc.

NDC 51991-172-45

Sulfatol™ Gel

Sodium Sulfacetamide 10% and Sulfur 5%

Rx ONLY

Net Wt. 1.5 fl. oz. (45mL)

Skin Gel

For The Topical Treatment Of

• Acne Vulgaris


• Acne Rosacea


• Seborrheic Dermatitis

SULFATOL  sulfacetamide sodium and sulfur  gel

Product Information Product Type HUMAN PRESCRIPTION DRUG NDC Product Code (Source) 51991-172 Route of Administration TOPICAL DEA Schedule

Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength Sulfacetamide Sodium (Sulfacetamide) Sulfacetamide Sodium 100 mg  in 1 mL Sulfur (Sulfur) Sulfur 50 mg  in 1 mL

Inactive Ingredients Ingredient Name Strength Urea   benzyl alcohol   cetyl alcohol   coco-glycerides   dimethicone   Edetate Disodium   Polyoxyl 100 Stearate   isopropyl myristate   light mineral oil   polysorbate 60   propylene glycol   sodium thiosulfate   sorbitan monostearate   stearyl alcohol   water   xanthan gum   zinc ricinoleate   glyceryl monostearate

Product Characteristics Color YELLOW (yellow, smooth) Score      Shape Size Flavor Imprint Code Contains

Packaging # NDC Package Description Multilevel Packaging 1 51991-172-45 1 TUBE In 1 CARTON contains a TUBE 1 45 mL In 1 TUBE This package is contained within the CARTON (51991-172-45)

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
UNAPPROVED DRUG OTHER		03/01/2005	09/30/2011

Labeler - Breckenridge Pharmaceutical, Inc. (150554335)

Establishment
Name	Address	ID/FEI	Operations
Groupe Parima		252437850	MANUFACTURE

Revised: 12/2010Breckenridge Pharmaceutical, Inc.

More Sulfatol Gel resources

• Sulfatol Gel Side Effects (in more detail)
• Sulfatol Gel Use in Pregnancy & Breastfeeding
• Sulfatol Gel Drug Interactions
• Sulfatol Gel Support Group
• 0 Reviews for Sulfatol - Add your own review/rating

Compare Sulfatol Gel with other medications

• Acne
• Rosacea
• Seborrheic Dermatitis

Urinary Retention Medications

Definition of Urinary Retention: Urinary retention is the inability to pass urine.

Drugs associated with Urinary Retention

The following drugs and medications are in some way related to, or used in the treatment of Urinary Retention. This service should be used as a supplement to, and NOT a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

Learn more about Urinary Retention

Micromedex Care Notes:

• Acute Urinary Retention In Women
• Neurogenic Bladder After Spinal Cord Injury
• Urinary Retention In Men
• Urostomy Care

Medical Encyclopedia:

• Neurogenic bladder
• Urge incontinence
• Urination - difficulty with flow

Drug List:

Duvoid

Urecholine

In-111 Zevalin

Generic Name: ibritumomab (ib ri TYOO mo mab)

Brand Names: In-111 Zevalin, Y-90 Zevalin

What is In-111 Zevalin (ibritumomab)?

Ibritumomab is a protein that targets white blood cells in the body. When ibritumomab is attached to a radioactive chemical, the radiation is delivered directly to the tumor (lymphoma).

Ibritumomab is used in combination with other medicines to treat non-Hodgkin's lymphoma.

Ibritumomab may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about In-111 Zevalin (ibritumomab)?

Do not receive this medication if you are pregnant. It could cause harm to the unborn baby. Use an effective form of birth control, and tell your doctor if you become pregnant during treatment. Do not receive a "live" vaccine while you are being treated with ibritumomab, and avoid coming into contact with anyone who has recently received a live vaccine. There is a chance that the virus could be passed on to you.

Some people receiving ibritumomab have developed "secondary" bone marrow or blood cell cancers such as leukemia. Talk with your doctor about your individual risk while receiving this medication.

What should I discuss with my healthcare provider before receiving In-111 Zevalin (ibritumomab)?

You should not receive this medication if you are allergic to ibritumomab, or to radioactive chemicals or mouse proteins.

Before you receive ibritumomab, tell your doctor if you are allergic to any drugs, or if you have:

• liver disease;


• kidney disease;


• 
  

  any type of infection;

  
  


• 
  

  lung or breathing problems;

  
  


• 
  

  bleeding or blood clotting problems;

  
  


• 
  

  low platelet counts;

  
  


• 
  

  low blood pressure; or

  
  


• 
  

  a history of heart disease, heart attack, angina (chest pain), or irregular heart beats.

  
  

It is not known whether ibritumomab passes into breast milk or if it could harm a nursing baby. Do not receive ibritumomab without telling your doctor if you are breast-feeding a baby.

Some people receiving ibritumomab have developed "secondary" bone marrow or blood cell cancers such as leukemia. Talk with your doctor about your individual risk while receiving this medication.

How is ibritumomab used?

Ibritumomab is used in combination with rituximab (Rituxan) and a radioactive chemical. Ibritumomab is given as an injection through a needle placed into a vein. Your doctor, nurse, or other healthcare provider will give you this injection.

Ibritumomab is usually given every 7 to 9 days. Follow your doctor's instructions.

What happens if I miss a dose?

Contact your doctor if you miss an appointment for your ibritumomab injection.

What happens if I overdose?

Overdose symptoms may include weakness, pale skin, and easy bruising or bleeding.

What should I avoid while using In-111 Zevalin (ibritumomab)?

Do not receive a "live" vaccine while you are being treated with ibritumomab, and avoid coming into contact with anyone who has recently received a live vaccine. There is a chance that the virus could be passed on to you.

In-111 Zevalin (ibritumomab) side effects

Some people receiving an ibritumomab injection have had a reaction to the infusion (when the medicine is injected into the vein). Tell your caregiver right away if you feel dizzy, nauseated, light-headed, sweaty, itchy, or have a fast heartbeat, trouble breathing, chest pain or heavy feeling, or pain spreading to the arm or shoulder. These reactions can occur during the injection or within 24 hours afterward.

Less serious side effects may include:

• 
  

  nausea, vomiting, loss of appetite;

  
  


• 
  

  anxiety;

  
  


• 
  

  dizziness; or

  
  


• 
  

  joint pain.

  
  

What other drugs will affect In-111 Zevalin (ibritumomab)?

This list is not complete and there may be other drugs that can interact with ibritumomab. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

More In-111 Zevalin resources

• In-111 Zevalin Side Effects (in more detail)
• In-111 Zevalin Use in Pregnancy & Breastfeeding
• In-111 Zevalin Drug Interactions
• In-111 Zevalin Support Group
• 0 Reviews for In-111 Zevalin - Add your own review/rating

• In-111 Zevalin MedFacts Consumer Leaflet (Wolters Kluwer)


• ibritumomab Intravenous Advanced Consumer (Micromedex) - Includes Dosage Information


• Ibritumomab Tiuxetan Monograph (AHFS DI)


• Y-90 Zevalin MedFacts Consumer Leaflet (Wolters Kluwer)

Compare In-111 Zevalin with other medications

• Non-Hodgkin's Lymphoma

Where can I get more information?

• Your doctor or pharmacist can provide more information about ibritumomab.

See also: In-111 Zevalin side effects (in more detail)

Hemabate

Generic Name: carboprost (KAR boe prost)

Brand Names: Hemabate

What is Hemabate (carboprost)?

Carboprost is a form of prostaglandin (a hormone-like substance that occurs naturally in the body). Prostaglandins help to control functions in the body such as blood pressure and muscle contractions.

Carboprost is used to treat severe bleeding after childbirth (postpartum).

Carboprost is also used to produce an abortion by causing uterine contractions. It is usually given between the 13th and 20th weeks of pregnancy, but may be given at other times for medical reasons. Carboprost is often used when another method of abortion has not completely emptied the uterus, or when a complication of pregnancy would cause the baby to be born too early to survive.

Carboprost may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Hemabate (carboprost)?

Carboprost usually causes nausea, vomiting, and/or diarrhea. You may be given to control these things before you are given carboprost.

You should not receive this medication if you are allergic to carboprost, or have certain conditions such as pelvic inflammatory disease, a breathing disorder, heart disease, liver disease, or kidney disease. Serious side effects of carboprost may include severe pelvic cramping, vaginal bleeding, high fever, and severe vomiting or diarrhea.

Before you receive carboprost, tell your doctor if you have been treated with any other drugs that may cause contractions of the uterus. Carboprost can increase the effects of these other drugs, and they should not be used together.

Your cervix (opening of the uterus) will need to be checked after you receive carboprost. Do not miss any scheduled follow-up visits to your doctor.

In some cases, carboprost may not produce a complete abortion and the procedure must be repeated.

What should I discuss with my health care provider before receiving Hemabate (carboprost)?

You should not receive this medication if you are allergic to carboprost, or have certain conditions. Tell your doctor if you have:

• 
  

  pelvic inflammatory disease;

  
  


• 
  

  a lung disorder or breathing problem;

  
  


• 
  

  heart disease;

  
  


• 
  

  kidney disease; or

  
  


• 
  

  liver disease.

  
  

Before receiving carboprost, tell your doctor if you are allergic to any drugs, or if you have:

• 
  

  high or low blood pressure;

  
  


• 
  

  diabetes;

  
  


• 
  

  epilepsy or other seizure disorder;

  
  


• 
  

  any scarring in your uterus;

  
  


• 
  

  a history of asthma; or

  
  


• 
  

  a history of heart, kidney, or liver disease.

  
  

If you have any of these conditions, you may not be able to receive carboprost, or you may need dosage adjustments or special tests during treatment.

If you are receiving this medication for purposes other than abortion or postpartum bleeding, tell your doctor if you are pregnant.

How is carboprost given?

Carboprost is given as an injection into a muscle. You will receive this injection in a clinic or hospital setting.

You may also be given medication to control nausea, vomiting, or diarrhea caused by carboprost.

To be sure this medication has been effective, your cervix (opening of the uterus) will need to be checked after the procedure. Do not miss any scheduled follow-up visits to your doctor.

In some cases, carboprost may not produce a complete abortion and the procedure must be repeated.

What happens if I miss a dose?

Since this medication is given as needed by a healthcare professional, it is not likely that you will miss a dose.

What happens if I overdose?

Tell your caregivers right away if you think you have received too much of this medicine. An overdose of carboprost is unlikely to occur in a hospital or clinic setting.

What should I avoid while receiving Hemabate (carboprost)?

Follow your doctor's instructions about any restrictions on food, beverages, or activity after you receive carboprost.

Hemabate (carboprost) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

• 
  

  severe pelvic pain, cramping, or vaginal bleeding;

  
  


• 
  

  high fever;

  
  


• 
  

  feeling light-headed or short of breath;

  
  


• 
  

  severe nausea, vomiting, or diarrhea; or

  
  


• 
  

  increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure).

  
  

Less serious side effects include:

• 
  

  mild fever that may come and go;

  
  


• 
  

  chills, numbness, or tingly feeling;

  
  


• 
  

  mild nausea or diarrhea;

  
  


• 
  

  cough;

  
  


• 
  

  headache;

  
  


• 
  

  breast pain or tenderness;

  
  


• 
  

  menstrual type pain; or

  
  


• 
  

  ringing in your ears.

  
  

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Hemabate (carboprost)?

Before you receive carboprost, tell your doctor if you have been treated with any other drugs that may cause contractions of the uterus, such as:

• 
  

  dinoprostone (Prostin E2);

  
  


• 
  

  mifepristone (Mifeprex (RU-486)

  
  


• 
  

  misoprostol (Cytotec); or

  
  


• 
  

  oxytocin (Pitocin).

  
  

Carboprost can increase the effects of these other drugs, and they should not be used together.

This list it not complete and there may be other drugs that can affect carboprost. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

More Hemabate resources

• Hemabate Side Effects (in more detail)
• Hemabate Use in Pregnancy & Breastfeeding
• Hemabate Support Group
• 0 Reviews for Hemabate - Add your own review/rating

• Hemabate Prescribing Information (FDA)


• Hemabate Monograph (AHFS DI)


• Hemabate Advanced Consumer (Micromedex) - Includes Dosage Information

Compare Hemabate with other medications

• Abortion
• Postpartum Bleeding

Where can I get more information?

• Your doctor or pharmacist can provide more information about carboprost.

See also: Hemabate side effects (in more detail)

Artificial Saliva Spray

Generic Name: Artificial Saliva
Brand Name: Salivart

Artificial Saliva Spray is used for:

Relieving dry mouth and throat.

Artificial Saliva Spray is an artificial saliva. It works by moistening and lubricating the mouth and throat.

Do NOT use Artificial Saliva Spray if:

• you are allergic to any ingredient in Artificial Saliva Spray

Contact your doctor or health care provider right away if any of these apply to you.

Before using Artificial Saliva Spray:

Some medical conditions may interact with Artificial Saliva Spray. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances

Some MEDICINES MAY INTERACT with Artificial Saliva Spray. However, no specific interactions with Artificial Saliva Spray are known at this time.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Artificial Saliva Spray may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Artificial Saliva Spray:

Use Artificial Saliva Spray as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Spray 1 or 2 times into the mouth whenever it feels uncomfortably dry.


• If you miss taking a dose of Artificial Saliva Spray for 1 or more days, there is no cause for concern. If your doctor recommended that you take it, try to remember your dose every day.

Ask your health care provider any questions you may have about how to use Artificial Saliva Spray.

Important safety information:

• PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Artificial Saliva Spray, discuss with your doctor the benefits and risks of using Artificial Saliva Spray during pregnancy. It is unknown if Artificial Saliva Spray is excreted in breast milk. If you are or will be breast-feeding while you are using Artificial Saliva Spray, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Artificial Saliva Spray:

All medicines may cause side effects, but many people have no, or minor, side effects. When used in small doses, no COMMON side effects have been reported with this product. Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Artificial Saliva Spray:

Store Artificial Saliva Spray at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Do not refrigerate. Store away from heat, moisture, and light. Do not store in the bathroom. Store away from heat and direct sunlight. Do not puncture, break, or burn the canister even if it appears to be empty. Keep Artificial Saliva Spray out of the reach of children and away from pets.

General information:

• If you have any questions about Artificial Saliva Spray, please talk with your doctor, pharmacist, or other health care provider.


• Artificial Saliva Spray is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Artificial Saliva Spray. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Artificial Saliva resources

• Artificial Saliva Use in Pregnancy & Breastfeeding
• Artificial Saliva Support Group
• 2 Reviews for Artificial Saliva - Add your own review/rating

Compare Artificial Saliva with other medications

• Mucositis
• Xerostomia

Prosed/DS

Generic Name: hyoscyamine, methenamine, methylene blue, and phenyl salicylate (HYE oh SYE a meen, meth EN a meen, METH il een BLUE, FEEN il sa LIS il ate)

Brand Names: Darpaz, Hyophen, Phosenamine, Phosphasal, Prosed/DS, Urelle, Uribel, Uro Blue, Ustell, Uta, UTICAP, Utira, Utira-C

What is Prosed/DS (hyoscyamine, methenamine, methylene blue, and phenyl salicylate)?

Hyoscyamine produces many effects in the body, including relief from muscle spasms.

Methenamine and methylene blue work as mild antiseptics that fight bacteria in the urine and bladder.

Phenyl salicylate is a mild pain reliever.

The combination of hyoscyamine, methenamine, methylene blue, and phenyl salicylate is used to treat bladder irritation (pain, burning, inflammation) caused by urinary tract infection. This medication is also used to prevent bladder discomfort during a medical procedure.

Hyoscyamine, methenamine, methylene blue, and phenyl salicylate may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Prosed/DS (hyoscyamine, methenamine, methylene blue, and phenyl salicylate)?

You should not use hyoscyamine, methenamine, methylene blue, and phenyl salicylate if you are allergic to it.

Before taking this medication, tell your doctor if you have any type of heart problem (congestive heart failure, coronary heart disease, a heart valve or heart rhythm disorder), glaucoma, an enlarged prostate, bladder obstruction, myasthenia gravis, a stomach ulcer or obstruction, or if you are allergic to belladonna (Donnatal and others).

Drink plenty of liquids while you are taking this medication. If you have an eye exam and your pupils are dilated with eye drops, tell the eye doctor ahead of time that you are using hyoscyamine, methenamine, methylene blue, and phenyl salicylate.

Many drugs can interact with this medicine. Also, hyoscyamine can make it harder for your body to absorb other medications you take by mouth. Tell your doctor about all other medicines you use.

What should I discuss with my healthcare provider before taking Prosed/DS (hyoscyamine, methenamine, methylene blue, and phenyl salicylate)?

You should not use hyoscyamine, methenamine, methylene blue, and phenyl salicylate if you are allergic to it.

To make sure you can safely take this medication, tell your doctor if you have any of these other conditions:

• 
  

  heart disease;

  
  


• 
  

  a heart rhythm disorder;

  
  


• 
  

  congestive heart failure;

  
  


• 
  

  coronary heart disease;

  
  


• 
  

  a heart valve disorder;

  
  


• 
  

  glaucoma;

  
  


• 
  

  an enlarged prostate or bladder obstruction;

  
  


• 
  

  myasthenia gravis;

  
  


• 
  

  an ulcer or obstruction in your stomach; or

  
  


• 
  

  if you are allergic to belladonna (Donnatal and others).

  
  

FDA pregnancy category C. It is not known whether this medication will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Hyoscyamine, methenamine, methylene blue, and phenyl salicylate can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Hyoscyamine, methenamine, methylene blue, and phenyl salicylate should not be given to a child younger than 7 years old. Older adults may be more likely to have side effects from this medication.

How should I take Prosed/DS (hyoscyamine, methenamine, methylene blue, and phenyl salicylate)?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Hyoscyamine, methenamine, methylene blue, and phenyl salicylate is usually taken 4 times daily. Follow your doctor's instructions.

Do not crush, chew, or break an enteric coated pill. Swallow it whole. The enteric coated pill has a special coating to protect your stomach. Breaking the pill will damage this coating. Drink plenty of liquids while you are taking this medication. If you have an eye exam and your pupils are dilated with eye drops, tell the eye doctor ahead of time that you are using hyoscyamine, methenamine, methylene blue, and phenyl salicylate. Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe dizziness or rapid pulse.

What should I avoid while taking Prosed/DS (hyoscyamine, methenamine, methylene blue, and phenyl salicylate)?

Avoid taking an antacid or anti-diarrhea medicine within 1 hour before or after you take hyoscyamine, methenamine, methylene blue, and phenyl salicylate. Antacids or anti-diarrhea medicine can make it harder for your body to absorb hyoscyamine.

If you also take ketoconazole (Nizoral), wait at least 2 hours after taking it before you take hyoscyamine, methenamine, methylene blue, and phenyl salicylate.

Prosed/DS (hyoscyamine, methenamine, methylene blue, and phenyl salicylate) side effects

Methylene blue will most likely cause your urine or stools to appear blue or green in color. This is a normal side effect of the medication and will not cause any harm.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have a serious side effect such as:

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  severe dizziness, blurred vision, fast heart rate;

  
  


• 
  

  agitation, confusion, feeling restless or excited;

  
  


• 
  

  painful or difficult urination; or

  
  


• 
  

  feeling short of breath.

  
  

Less serious side effects may include:

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  mild dizziness;

  
  


• 
  

  drowsiness; or

  
  


• 
  

  flushing (warmth, redness, or tingly feeling).

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Prosed/DS (hyoscyamine, methenamine, methylene blue, and phenyl salicylate)?

Many drugs can interact with this medicine. Also, hyoscyamine can make it harder for your body to absorb other medications you take by mouth. Tell your doctor about all other medicines you use, especially:

• 
  

  atropine (Atreza, Sal-Tropine), belladonna (Donnatal, and others), benztropine (Cogentin), dimenhydrinate (Dramamine), methscopolamine (Pamine), or scopolamine (Transderm Scop);

  
  


• 
  

  a diuretic (water pill);

  
  


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  bronchodilators such as ipratropium (Atrovent) or tiotropium (Spiriva);

  
  


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  glycopyrrolate (Robinul);

  
  


• 
  

  homatropine (Hycodan, Tussigon);

  
  


• 
  

  methantheline;

  
  


• 
  

  neostigmine (Prostigmin) or pyridostigmine (Mestinon);

  
  


• 
  

  bladder or urinary medications such as darifenacin (Enablex), flavoxate (Urispas), oxybutynin (Ditropan, Oxytrol), tolterodine (Detrol), or solifenacin (Vesicare); or

  
  


• 
  

  an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate);

  
  


• 
  

  medicines to treat symptoms of Alzheimer's disease such as donepezil (Aricept), galantamine (Razadyne), memantine (Namenda), rivastigmine (Exelon), or tacrine (Cognex);

  
  


• 
  

  narcotic pain medication such as codeine (Tylenol #3, Cheratuss, Guaiatuss), fentanyl (Actiq, Duragesic), hydrocodone (Lortab, Vicodin, Vicoprofen), hydromorphone (Dilaudid), methadone (Dolophine, Methadose), morphine (Avinza, Kadian, MS Contin, Oramorph), oxycodone (OxyContin, Endocet, Percocet), propoxyphene (Darvocet, Propacet), and others;

  
  


• 
  

  sodium bicarbonate, potassium citrate (K-Lyte, Urocit-K), sodium citrate and citric acid (Bicitra, Oracit), or sodium citrate and potassium (Citrolith, Polycitra);

  
  


• 
  

  sulfa drugs (Bactrim, Septra, Sulfatrim, SMX-TMP, and others); or

  
  


• 
  

  ulcer or irritable bowel medications such as dicyclomine (Bentyl), glycopyrrolate (Robinul), hyoscyamine (Hyomax), mepenzolate (Cantil), or propantheline (Pro Banthine).

  
  

This list is not complete and there are many other drugs that can interact with hyoscyamine, methenamine, methylene blue, and phenyl salicylate. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.

More Prosed/DS resources

• Prosed/DS Side Effects (in more detail)
• Prosed/DS Use in Pregnancy & Breastfeeding
• Prosed/DS Drug Interactions
• Prosed/DS Support Group
• 6 Reviews for Prosed/DS - Add your own review/rating

• Prosed/DS MedFacts Consumer Leaflet (Wolters Kluwer)


• Darcalma Prescribing Information (FDA)


• Darpaz Prescribing Information (FDA)


• Phosenamine Prescribing Information (FDA)


• Phosphasal Advanced Consumer (Micromedex) - Includes Dosage Information


• Phosphasal Prescribing Information (FDA)


• Prosed EC Advanced Consumer (Micromedex) - Includes Dosage Information


• Urelle Prescribing Information (FDA)


• Uribel Prescribing Information (FDA)


• Urimax Delayed-Release Tablets MedFacts Consumer Leaflet (Wolters Kluwer)


• Urised MedFacts Consumer Leaflet (Wolters Kluwer)


• Uritact-EC Delayed-Release Tablets MedFacts Consumer Leaflet (Wolters Kluwer)


• Ustell Prescribing Information (FDA)


• Uta MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Prosed/DS with other medications

• Urinary Tract Infection

Where can I get more information?

• Your pharmacist can provide more information about hyoscyamine, methenamine, methylene blue, and phenyl salicylate.

See also: Prosed/DS side effects (in more detail)